Protective Effects of Medroxyprogesterone Acetate on Testicular Cytotoxicity of Doxorubicin in Rats / 대한비뇨기과학회지

As the number of long-term survivors is increasing with recent advances of anticancer chemotherapeutics, the late toxic effects of anticancer agents are assuming increased importance. Many young men who have been successfully treated with antineoplastic agents develop azoospermia which persist long after cessation of treatment. Post-pubertal sexual development and spermatogenesis are often unaffected in males who have received chemotherapy before puberty. On the basis of this observation and from animal studies it has been suggested that chemotherapy-induced damage to spermatogenesis can be avoided or at least reduced by the induction of a "resting state" of the testes. This can be achieved by analogues of LH-RH or medroxyprogesterone acetate. The aim of present study was to evaluate protective effect from doxorubicin-induced testicular damage with medroxyprogesterone acetate in rats. 1. Comparing with control group, body weight was not changed in medroxyprogesterone acetate treated group. The rats which received doxorubicin displayed significant weight loss. Body weight was decreased more significantly in group III (doxorubicin only administration) than in group IV (medroxyprogesterone acetate and doxorubicin administrational(p <0.001) 2. Testicular weight was markedly decreased by medroxyprogesterone acetate injection but the weight was increased gradually after cessation of administration. In group III and group IV, testicular weights were also decreased markedly, but there was no difference between two groups(p <0.5 ). 3. Sperm head count was reduced with medroxyprogesterone acetate administration but the count was increased gradually after cessation of administration. In group III and group IV sperm head counts were also decreased but more significantly reduced in group III.( <0.005). 4. Repopulation index was diminished with medroxyprogesterone acetate administration up to medical castration level but repopulation index was returned to nearly normal after cessation of administration. In group III and group IV, repopulation indices were also diminished but more significantly diminished in group III.( p <0.005) With above results we can suggest that temporary interruption of the pituitary gonadal axis with medroxyprogesterone acetate may ameliorate the gonadal toxicity of doxorubicin therapy.

A Clinical Observation on the Nephrectomized Patients / 대한비뇨기과학회지

A retrospective analysis of 132 patients who underwent nephrectomy in the Department of Urology, Kyung Hee University Hospital, during the period from January 1972 to December 1980 was presented. The results were as follows: 1. The total number of in-patients during the above period was 2,301 and nephrectomies were performed in 132 of 1,427 total urologic operations (9.3%). 2. Age distribution showed the highest in 4th decade with 22.7%, the youngest was 11 months and the oldest 78 years, and male to female ratio was 68 to 64. 3. The causative diseases of the nephrectomy were renal tuberculosis 48 cases (36.4%), tumor 15 cases 11.4%. hydronephrosis 11 cases (8.3%), pyonephrosis 10 cases (7.6%), anomaly 8 cases (6.1%) and hypertension 6 cases (4.5%) in order. 4. Anterior abdominal extraperitoneal transverse approach was the most frequently used method in 103 cases (78.0%) 5. Post-operative complications were seen in 29 cases (22.0%), of which wound infection was common in anterior abdominal extraperitoneal transverse approach.

Clinical Observation on the Total Cystectomy of the Bladder tumor / 대한비뇨기과학회지

A retrospective analysis of 9 patients of bladder tumor who underwent total cystectomy in the Department of Urology. Kyung Hee University Hospital, during the period from May, 1977 to April, 1981. The results were as follows: 1. The age of the patients ranged from 52 to 65 years, the average age 59.8 years, and male to female ratio was 7 to 2. 2. Hematuria was the most commonly found in 9 patients, frequency in 5 patients, and dysuria in 3 patients. 3. Errors in clinical staging were also common-1 case was overstaged, 3 cases understaged, 3 cases corresponded and 2 casts inadequate for the clinical staging, but the pathologic grade proved to be equal that estimated from the 2 cases of transurethral biopsy. 4. There were 8 cases of total cystectomy and 1 case of radical cystectomy, the methods of urinary diversion and remodeling of urinary tract were ileal conduit in 6 cases, bilateral cutaneous ureterostomy in 3 cases. 5. Operative death was none but the complications were followed by total cystectomy and urinary diversion in 8 cases as wound disruption, pneumonia, atelectasis, irritation dermatitis, vaginal vault bleeding, pyelonephritis, stromal stricture, stricture of ureteroileal anastomosis site and delayed wound healing.

Clinical Observation on the Bladder Tumor / 대한비뇨기과학회지

A Clinical observation was made on the patients with bladder tumor admitted to the Department of Urology, Kyung Hee University Hospital during the period from January, 1973 to December,1979 Followings were the results: 1. During the period, 57 cases of bladder tumor among the 1716 total number of in-patients were hospitalized, giving a incidence rate of 3.3%. 2. Age distribution was between 4 and 85 years, the highest incidence rate was in the age group of 60-69 years. 3. Hematuria was the most common symptom occurred in 87.7%, frequency in 61.1%. dysuria in 52.6% and the others. 4. Among the 53 cases performed I.V.P., 79.3% of cases revealed normal upper tract, filling defect in the bladder was observed in 69.8% of them. 5. Associated diseases with bladder tumor were B. P. H. or B. N. C. each in 12.3% and U. T. I. in 31. 6%. 6. Pathologic examination was possible on 49 cases, transitional cell carcinoma occupied 44 cases, in 89.8% and Grade I was found most frequently. 7. 14 cases were studied by the non-invasive, simple method as computerized tomography: the effective staging procedure in invasion of bladder wall itself could be diagnosed very helpfully but distant metastasis not diagnosed very exactly, comparison with the operation stage. 8. 47 cases were treated, T. U. R. or T. U. C. were tried initially in 21 cases.

Renal Cell Carcinoma Involving the Renal Vein and Vena Cava / 대한비뇨기과학회지

A retrospective analysis of our experience with six patients of renal cell carcinoma involving the renal vein and vena cava are reported. Since neither chemotherapy nor radiation has significantly altered the course of these advanced cases, radical nephrectomy with complete removal of the tumor tissue seems to be the only effective treatment. Knowledge of the accurate extent and nature of caval involvement is essential in planning the appropriate surgical procedure. Venacavography should be performed in large renal tumors and nonvisualization of the kidney containing tumor.